Yes, when we faded to black back in May, both Izzie (Katherine Heigl) and George (T.R. Knight) were coding — she after suffering a setback in her treatment for metastatic skin cancer, he after deciding to join the Army, stepping in to help a stranger, and being hit by a bus. (Just George's luck.)
But by and large, we know what's happening, and it is the specifics that will come out in the season premiere, spoileriffically titled "Good Mourning/Goodbye."
source: http://www.buydvdezy.com/article-347-Greys-Anatomy-faces-season-of-change.html

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